Most antidepressants—like SSRIs (e.g., Zoloft, Lexapro) and SNRIs (e.g., Effexor)—can safely be continued during ketamine treatment. They don’t appear to interfere with its effects and may even work better after ketamine opens up new neural pathways.

Benzodiazepines (e.g., Xanax, Klonopin, Ativan) are more complicated. They calm the nervous system, but they can also blunt the emotional and psychological depth of ketamine. If you take benzos regularly, your provider might recommend adjusting your dose—or pausing use around the session—but never without medical guidance, since stopping abruptly can be dangerous.

Stimulants (e.g., Adderall, Vyvanse, Ritalin) may raise your heart rate or contribute to anxiety during a ketamine session. Your provider may ask you to skip your dose that day or take it earlier, depending on your reaction and history.

Be open and honest about every medication or supplement you’re taking. A good provider will tailor your treatment plan safely and thoughtfully around your needs.